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Objective To explore the effects of Wenxin granule combined with conventional therapy on cardiac function,ventricular remodeling and local inflammatory response in patients with paroxysmal atrial fibrillation (PAF).Methods From February 2016 to February 2017,116 patients with PAF in the Integrated Traditional Chinese and Western Medicine Hospital of Taizhou were randomly divided into control group(55 cases) and combined group(61 cases) according to the digital table.The control group was treated with routine amiodarone hydrochloride tablets and enalapril maleate tablets,and the combined group was treated with Wenxin granule on the basis of the control group.The clinical efficacy of the two groups was compared,and the cardiac function,the level of inflammatory reaction and the index of ventricular remodeling before and after treatment were compared and analyzed in the two groups.The adverse reactions were observed and analyzed in the two groups.Results The total effective rate in the combined group was 93.44％,which was significantly higher than 76.36％ in the control group (x2 =6.745,P ＜ 0.05).After treatment,the left atrial diameter,the FS and CI levels in the combined group were significantly higher than those in the control group and before treatment (all P ＜ 0.05).The level of Pd in the combined group after treatment was (47.16 ± 0.80) ms,,which was significantly lower than that in the control group [(50.25 ± 0.75) ms] and that before treatment (t =21.395,48.318,all P ＜ 0.05).The levels of hs-CRP and BNP in the combined group were (7.12 ± 2.71) mg/L,(118.43 ± 11.16) ng/L,respectively,which were significantly lower than those in the control group [(11.21 ± 2.89) mg/L,(123.6 ± 11.27) ng/L] and before treatment (t =7.865,2.504,8.585,8.752,all P ＜0.05).After treatment,the LVEF level in the combined group was higher than that in the control group and before treatment (t =4.785,10.573,all P ＜ 0.05).The LVEDD and LVSV levels in the combined group were significantly lower than those in the control group and before treatment (t =9.089,2.313,10.890,4.299,all P ＜ 0.05).The total incidence rate of adverse reactions in the combined group was 6.56％,which was slightly lower than 7.28％ in the control group,but there was no statistically significant difference between the two groups(x2 =0.023,P＞0.05).Conclusion Wenxin granule combined with routine treatment in the treatment of PAF can significantly improve the clinical efficacy,improve the cardiac function obviously,delaye the ventricular remodeling,decrease the level of local inflammatory reaction significantly and the safety is high.
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Background and purpose:Cancer microenvironment has become a hot topic of cancer research. It is important in the initiation of colorectal cancer. This study aimed to discuss the correlation between the characteristics of tissue culturein vitro and different cell types in cancer microenvironment.Methods:Samples were collected at different distances from the colorectal cancer lesions, which were named as positions 1, 2 and 3 from distal to proximal. Tissues were cut into 1-2 mm3 forin vitro culturing. HE staining was used to observe the structure of crypts. Immunohistochemistry was used to detect the expressions of Cyclin D1 (CD1), CD133, cytokeratin18 (CK18), vimentin and α-smooth muscle actin (α-SMA).Results:Position 3 grew faster than position 2 and position 1. As getting closer to the colorectal cancer lesions, expressions of CD1, CD133, vimentin and α-SMA were increased while expression of CK18 was decreased.Conclusion:The tissue structure and the expression of different cell types in cancer microenvironment changed more seriously as get-ting closer to the colorectal cancer lesions. This indicated that the change of cancer microenvironment may contribute to the initiation of colorectal cancer.
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Objective To explore the application effect of home care on the basis of temperament combined with social competence in preschool children with bronchial asthma.Methods A total of 100 preschool children outpatients with bronchial asthma who came to our hospital from January 1 to February 28,2013 were selected with the method of convenience sampling and were randomly divided into observed group and control group with 50 cases in each group.Cases of the observed group were divided into ordinary,middle,and strengthen subgroups according to temperament and social competence.The control group and the ordinary subgroup received routine care interventions,and the other subgroups were given corresponding enhanced care measures.The attack rate of asthma,medical care,quality of life and lung function during one year follow-up were observed and compared between the two groups.Results Within the first six months of follow-up,patients in observed group got better control in acute attacks than the control group [(2.3±0.4) times vs.(3.4±0.3) times,x2=5.710,P＜0.05)].The percentage of forced expiratory volume in the first second and Pediatric Asthma Quality of Life Questionnaire scores in observed group were significantly higher than the control group one years later [(86.9±4.6)％ vs.(85.5±3.8)％ and (90.1±7.5) vs.(76.5±8.0),P＜0.05].Conclusions The application of temperament type combined with social competence showed a good practical value in home care for asthma preschoolers.
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To programming one Child's Behavior Problems Computer Screening System (CBPCSS), a series of software for analyzing child behavior individual and group sample. According to the world-famous American ACHENBACH child's behavior checklist, to ensure the screening quality and compatibility of cultures, we revised and standardized the norms of different ages in primary schools and nursery schools in various cities based on the principle of cluster stratified sampling. Then we designed CBPCSS carefully. The system can reliably and rapidly screen an individual child behavior and output the behavior factor curve (appearing in front of the profile). With CBPCSS we can observe the child behavior clearly. It takes twenty times shorter than that of manual screening. On the other hand, CBPCSS has a function of group analysis. The clinical practice proved that CBPCSS could substitute for manual screening completely. It is a powerful tool for social, scientific and pediatric medical workers.
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Antitumor activity of 40% -alcoholic extract from Trachyrhamphus serratus (Temminck et SchlegeDwas assayed by using Heps and EAS tumor models of mice. The results showed the antitumor rate of water -eluted from macroporous absorbing resigns column was 50. 75% on cultured Heps of mice.